1) to run

a) of persons in haste

b) of those who run in a race course

2) metaph.

a) of doctrine rapidly propagated

b) by a metaphor taken from runners in a race, to exert one's self, strive hard

c) to spend one's strength in performing or attaining something

d) word occurs in Greek writings denoting to incur extreme peril, which it requires the exertion of all one's effort to overcome